A PRACTICAL STEREOSELECTIVE SYNTHESIS OF ,4S)4-TERT-BUTOXYCARBONYLAMINO-2-METHYLPYRROLIDINE

Authors
LI Q CHU DTW RAYE K CLAIBORNE A SEIF L MACRI B PLATTNER JJ
Citation
Q. Li et al., A PRACTICAL STEREOSELECTIVE SYNTHESIS OF ,4S)4-TERT-BUTOXYCARBONYLAMINO-2-METHYLPYRROLIDINE, Tetrahedron letters, 36(46), 1995, pp. 8391-8394
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
46
Year of publication
1995
Pages
8391 - 8394
Database
ISI
SICI code
0040-4039(1995)36:46<8391:APSSO,>2.0.ZU;2-Y
Abstract
Two practical syntheses of (2S, S)-4-tert-butoxycarbonylamino-2-methyl pyrrolidine, an important intermediate for quinolone antibacterial age nts, have been developed through the combination of diastereo and enan tioselective reactions starting from ethyl crotonate and L-alanine, re spectively.