ALKALOIDS FROM THE FUNGUS PENICILLIUM AURANTIO-VIRENS BIOURGE AND SOME ASPECTS OF THEIR FORMATION

The ability of the fungus Penicillium aurantio-virens VKM F-229 to pro duce clavine alkaloids was studied. The culture was found to possess t wo alternative pathways for clavine alkaloid synthesis and the ability to synthesize agroclavine, chanoclavine-I, elymoclavine, penniclavine , and isopenniclavine, in addition to aurantioclavine described earlie r. The conditions for production of these alkaloids are more limited a nd specific. A stimulatory action of exogenous chanoclavine-I on biosy nthesis of aurantioclavine was revealed.