SULFADOXINE PYRIMETHAMINE OR CHLOROQUINE CLINDAMYCIN TREATMENT OF GABONESE SCHOOL-CHILDREN INFECTED WITH CHLOROQUINE-RESISTANT MALARIA

Authors
METZGER W MORDMULLER B GRANINGER W BIENZLE U KREMSNER PG
Citation
W. Metzger et al., SULFADOXINE PYRIMETHAMINE OR CHLOROQUINE CLINDAMYCIN TREATMENT OF GABONESE SCHOOL-CHILDREN INFECTED WITH CHLOROQUINE-RESISTANT MALARIA, Journal of antimicrobial chemotherapy, 36(4), 1995, pp. 723-728
Citations number
10
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
36
Issue
4
Year of publication
1995
Pages
723 - 728
Database
ISI
SICI code
0305-7453(1995)36:4<723:SPOCCT>2.0.ZU;2-J
Abstract
a randomized trial, a high dosage chloroquine monotherapy (45 mg/kg ov er 3 days) was compared with combination regimens of sulfadoxine/pyrim ethamine and chloroquine/clindamycin for treating Gabonese school chil dren with Plasmodium falciparum malaria. In chloroquine treated patien ts only 32% were ultimately cured. In contrast, more than 90% of patie nts were cured after treatment with either combination regimen.