FUNCTIONALIZED ALPHA,BETA-UNSATURATED THIOAMIDES VIA HORNER-EMMONS REACTIONS

Authors
LEROYGOURVENNEC S MASSON S
Citation
S. Leroygourvennec et S. Masson, FUNCTIONALIZED ALPHA,BETA-UNSATURATED THIOAMIDES VIA HORNER-EMMONS REACTIONS, Synthesis, (11), 1995, pp. 1393
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
11
Year of publication
1995
Database
ISI
SICI code
0039-7881(1995):11<1393:FATVHR>2.0.ZU;2-T
Abstract
The reaction of a phosphonodithioacetate with amines (in particular fu nctionalised amines) leads to thiocarbamoylmethylphosphonates (unsubst ituted at the carbon alpha to the phosphoryl group), which can be used as Horner-Emmons reagents. This pathway is a very convenient and gene ral synthesis of functionalised thiocarbamoylphosphonates and alpha,be ta-unsaturated thioamides (in particular new amino acid derivatives).