SYNTHESIS OF BIS(TRIFLUOROMETHYL)-SUBSTITUTED OLEFINS - METHODS OF PREPARATION AND PROPERTIES

Several bis(trifluoromethyl)- and trifluoromethyl-substituted alkenes, dienes, arylalkenes, and alpha,beta-unsaturated derivatives of carbon yl compounds such as tosylhydrazone 5b and diazomethane 5c were prepar ed. Their reactivity towards a variety of nucleophiles, resulting from the electron-withdrawing effect of the trifluoromethyl group, was inv estigated. Depending on the trifluoromethyl- and a bis(trifluoromethyl )-substituted double bond, different regioselectivities were observed in the reaction with morpholinocyclohexene as a nucleophile. An explan ation is given on the basis of the C-13-NMR data.