SIMULIDIN - A BLACK FLY (SIMULIUM-VITTATUM) SALIVARY-GLAND PROTEIN WITH ANTI-THROMBIN ACTIVITY

Authors
ABEBE M CUPP MS CHAMPAGNE D CUPP EW
Citation
M. Abebe et al., SIMULIDIN - A BLACK FLY (SIMULIUM-VITTATUM) SALIVARY-GLAND PROTEIN WITH ANTI-THROMBIN ACTIVITY, Journal of insect physiology, 41(11), 1995, pp. 1001-1006
Citations number
22
Categorie Soggetti
Entomology
Journal title
Journal of insect physiology → ACNP
ISSN journal
00221910
Volume
41
Issue
11
Year of publication
1995
Pages
1001 - 1006
Database
ISI
SICI code
0022-1910(1995)41:11<1001:S-ABF(>2.0.ZU;2-Z
Abstract
A protein purified from the salivary gland lysate of female Simulium v ittatum was found to inhibit bovine alpha-thrombin. This protein is st able to heat, has a mass of 11,334 Da and is rich in threonine, Based on N-terminal sequencing for the first 35 amino acids, no significant sequence similarity with other proteins was detected, indicating that this salivary component may be unique in structure, Because of its sou rce and its anti-hemostatic properties, this protein has been named si mulidin.