APOLIPOPROTEIN A1-DERIVED AMYLOID IN HUMAN AORTIC ATHEROSCLEROTIC PLAQUES

Amyloid deposits in the aortic intima are very common in association w ith atherosclerosis and aging. In the present study, a major fibril pr otein purified form amyloid present in human athero-sclerotic plaques was shown to be a 69-amino acid N-terminal fragment of apolipoprotein Al. Although a senile form of localized apolipoprotein al-derived amyl oidosis has recently been documented in pulmonary vessels of dogs, thi s is the first example of a localized human amyloid derived from this apolipoprotein.