L. Imzil et Mk. Elamrani, ENTRAPMENT OF NEW BETA-BLOQUANTS IN EGG L ECITHIN LIPOSOMES - RELATIONS BETWEEN CHEMICAL-STRUCTURE AND RELEASE KINETICS OF THE DRUGS, Journal de chimie physique et de physico-chimie biologique, 94(1), 1997, pp. 18-30
Phospholipid liposomes were prepared from egg phosphatidylcholine acco
rding to the injection method. Turbidity measurements and dynamic ligh
t scattering were used to characterize the liposomes and to study thei
r stability during storage. The injection method gives reproductible a
nd stable liposome suspensions. The liposomes were small unilamellar v
esicles (SUV) with a mean diameter of about 100 nm. New beta-bloquants
and sodium salicylate have been entrapped in liposomes and release ki
netics has been studied. The entrapment efficiency was correlated to t
he octanol/water partition coefficients of the drugs. The relation bet
ween drug lipophilicity and release kinetics have been discussed using
two different kinetic models.