VIGABATRIN-ASSOCIATED REVERSIBLE ACUTE-PSYCHOSIS IN A CHILD

OBJECTIVE: To describe a child with vigabatrin-associated reversible a cute psychosis and review the literature reports on this adverse effec t. CASE SUMMARY: A 7-year-old boy with intractable epilepsy developed acute psychosis 3 days after initiating a rapid vigabatrin dosage esca lation. All symptoms resolved within 48 hours after vigabatrin therapy was withdrawn. Two months later, reinitiation of vigabatrin therapy u sing a slower dosage escalation was well-tolerated by the patient, and he currently is being treated with vigabatrin successfully. DISCUSSIO N: Although vigabatrin-associated psychosis is rare, a few cases have been reported in predisposed adult patients, especially in the early s tages of treatment. The mechanism of this reaction remains unclear and its incidence is unknown. To our knowledge, there has been no previou s report of this adverse effect in children. CONCLUSIONS: Caution must be taken in children with predisposing factors at the beginning of vi gabatrin therapy.