Since fewer donated corneas have become available for surgery, we soug
ht to chart the reasons to exclude them for surgical use over time. Th
ose excluded from surgical use (1991-1994) were plotted using an algor
ithm based on the reasons for exclusion. Four general categories (univ
ersal contraindications [UC], national/local medical criteria [NLMC],
serology, and morphology) yielded 13 possible areas. UC and NLMC exclu
sions for 1993-1994 were higher compared with 1991 and 1992 (p < 0.001
). The proportion of corneas excluded for serological reasons decrease
d (p < 0.001) from 1991 to 1994. Exclusions due to morphology remained
the same for all 4 years (p = NS). NLMC eliminate older donors but al
so exclude younger donors before the tissue reaches the eye bank (p >
0.001). Three of four of the youngest tissues (< 30 years) are used fo
r surgery, whereas one of five of the oldest (> 70 years) is used. A q
uality control algorithm provides a heuristic and logical paradigm for
noting changes from year to year. Heightened regulation has counterac
ted many gains in corneal donation fostered by favorable laws.