CONTINUOUS VERSUS INTERMITTENT BLADDER IRRIGATION OF AMPHOTERICIN-B FOR THE TREATMENT OF CANDIDURIA

Purpose: The efficacy of continuous versus intermittent bladder irriga tion with amphotericin B in the treatment of candiduria was compared. Materials and Methods: A prospective, randomized and comparative pilot study was done on 20 patients. Continuous bladder irrigation with 50 mg./l, amphotericin B infused during 24 hours for 2 days was compared to 3 intermittent bladder irrigations of 10 mg./100 ml. amphotericin B in 1 day. Urine cultures were obtained 72 hours after treatment. Resu lts: The organism was eradicated in 8 patients (80%) who received cont inuous irrigation and 3 (30%) who received intermittent irrigation (p = 0.035). Conclusions: Continuous amphotericin B bladder irrigation wa s superior in terms of efficacy, ease of administration and patient co mfort.