REINNERVATION OF THE RAT BLADDER WITH A SOMATIC NERVE AND A STRIATED-MUSCLE FLAP

Citation
M. Hohenfellner et al., REINNERVATION OF THE RAT BLADDER WITH A SOMATIC NERVE AND A STRIATED-MUSCLE FLAP, The Journal of urology, 154(6), 1995, pp. 2164-2169
Citations number
37
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
00225347
Volume
154
Issue
6
Year of publication
1995
Pages
2164 - 2169
Database
ISI
SICI code
0022-5347(1995)154:6<2164:ROTRBW>2.0.ZU;2-P
Abstract
Purpose: Current techniques of ventral sacral root stimulation to rega in voluntary motor control of the decentralized urinary bladder depend upon intact parasympathetic innervation of the detrusor. We investiga ted techniques that might allow restoration of motor control of the bl adder after efferent parasympathetic impairment. Materials and Methods : In a chronic rat model, we evaluated whether motor control of a peri pherally denervated bladder could be restored by transplantation of au tologous excitable tissues and subsequent electrostimulation. Either a somatic nerve or a striated muscle flap was used as the transplant. R esults: Four months after the initial surgery, electrostimulation of t he somatic nerve implant provoked bladder contractions-a response that was blocked by atropine. Stimulation of the nerve innervating the str iated muscle flap also provoked bladder contractions; these were not a ffected by atropine and were slightly reduced by hexamethonium. Conclu sion: Reinnervation of the bladder with somatic nerves or striated mus cles is possible in principle. Future experiments will clarify the cli nical significance of electrostimulation of such implants.