TUMOR-NECROSIS-FACTOR-ALPHA IN SERUM OF MACAQUES DURING SIVMAC251 ACUTE INFECTION

Authors
CLAYETTE P LEGRAND R NOACK O VASLIN B LENAOUR R BENVENISTE O THEODORO F FRETIER P DORMONT D
Citation
P. Clayette et al., TUMOR-NECROSIS-FACTOR-ALPHA IN SERUM OF MACAQUES DURING SIVMAC251 ACUTE INFECTION, Journal of medical primatology, 24(2), 1995, pp. 94-100
Citations number
50
Categorie Soggetti
Zoology,"Veterinary Sciences
Journal title
Journal of medical primatology → ACNP
ISSN journal
00472565
Volume
24
Issue
2
Year of publication
1995
Pages
94 - 100
Database
ISI
SICI code
0047-2565(1995)24:2<94:TISOMD>2.0.ZU;2-0
Abstract
TNF secretion was explored in sera during acute SIV-infection of cynom olgus macaques. A peak of TNF was detected in sera of animals in conco mitance with SIV replication. Likewise, AZT treatment delayed acid red uced peaks of viral replication and TNF production. Thus, SIVmac251-in fected monkey could be an excellent model to explore the interdigitati on existing between HIV and TNF in acute and chronic infection and to develop new therapeutic strategies that target the production of this cytokine or its inductive effects.