Pk. Sanyal, KINETIC DISPOSITION OF TRICLABENDAZOLE IN BUFFALO COMPARED TO CATTLE, Journal of veterinary pharmacology and therapeutics, 18(5), 1995, pp. 370-374
Concentrations of triclabendazole sulfoxide and its sulfone metabolite
in plasma were measured in buffalo and cross-bred cattle after single
intraruminal administration of triclabendazole at two different doses
. Plasma concentrations of both metabolites were significantly lower i
n buffalo than cattle at both doses, which resulted in a smaller area
under the concentration-time curve, a lower concentration maximum and
a lower relative bioavailability, Thus, the recommended doses of 12 mg
/kg body weight for the treatment of bubaline fascioliasis may not be
valid for buffalo because of the substantially lower uptake of the dru
g in this species.