ORAL PREVALENCE OF AEROBIC AND FACULTATIVELY ANAEROBIC GRAM-NEGATIVE RODS AND YEASTS IN HOSPITALIZED-PATIENTS

Saline oral rinse samples were obtained from 100 hospitalised patients in Hong Kong to determine the oral point prevalence of aerobic and fa cultatively anaerobic gram-negative rods (AGNR) and yeasts. AGNR and y easts were isolated from 59 per cent and 53 per cent of patients respe ctively. Enterobacteriaceae species comprised 50 per cent of all AGNR with an overall prevalence of 32 per cent. Enterobacteriaceae prevalen ce rates were higher in patients taking beta-adrenergic blocking agent s (P<0.01), angiotensin converting enzyme inhibitors (P<0.05), combina tions of antacids and analgesics (P<0.05) and combinations of antacids and antibiotics (P<0.05). In addition, Enterobacteriaceae prevalence was higher in patients hospitalised for longer than 15 days than in th ose hospitalised for 8-15 days (P<0.05). Candida albicans comprised 75 per cent of all yeasts isolated. Subjects over 60 years of age had a higher prevalence of yeasts than those under 60 (P<0.05). Patients wea ring dentures (n=25) had a higher oral yeast prevalence (76 per cent) than those not wearing dentures (45 per cent) (P<0.01). The impact, if any, of the high oral prevalence of AGNR in hospitalised patients on the outcome of their disease processes needs to be ascertained.