3',4'-DIETHYNYL-2',3',5'-TRIDEOXY-5'-NORURIDINE - A NEW SELF-POLYMERIZABLE 2'-DEOXYRIBONUCLEOSIDE ANALOG

Authors
AMIN MA STOECKLIEVANS H GOSSAUER A
Citation
Ma. Amin et al., 3',4'-DIETHYNYL-2',3',5'-TRIDEOXY-5'-NORURIDINE - A NEW SELF-POLYMERIZABLE 2'-DEOXYRIBONUCLEOSIDE ANALOG, Helvetica Chimica Acta, 78(7), 1995, pp. 1879-1886
Citations number
20
Categorie Soggetti
Chemistry
Journal title
Helvetica Chimica Acta → ACNP
ISSN journal
0018019X
Volume
78
Issue
7
Year of publication
1995
Pages
1879 - 1886
Database
ISI
SICI code
0018-019X(1995)78:7<1879:3-ANS>2.0.ZU;2-I
Abstract
In 10 steps, 3',4'-diethynyl-2',3',5'-trideoxy-5'-noruridine (14) was synthesized in 5% overall yield from commercial uridine, using convent ional methods of nucleoside chemistry. As two functional groups capabl e to react with each other are present in the same molecule, the synth etic compound is able to form polymers, similar to the polynucleotides , by acetylene coupling reaction.