TUMOR TARGETING THROUGH FIBROBLAST GROWTH-FACTOR RECEPTORS

Fibroblast growth factor tyrosine kinase receptors are encoded by four genes, but alternate splicing can result in more than 100 possible pr otein sequences. The receptors have widespread expression in the devel oping embryo, but the expression becomes more restricted in the adult. The ligand-receptor relationship is complex due to the diversity of t he receptors and the large number of possible ligands: there are now n ine (and probably more) members of the fibroblast growth factor family . This complicated ligand-receptor relationship creates many options t o target cell types through the use of individual ligands or receptor- specific monoclonal antibodies. In vivo data demonstrate that FGF rece ptors are expressed on tumor cells and can be used to target tumors fo r growth inhibition. Given the complexity, it is possible that a uniqu e targetable FGF receptor isoform can be found in. one or more tumor t ypes. Examples of the targeting of growth inhibition agents to tumors through FGF receptors are discussed. (C) 1995 Academic Press Ltd