OLIGOSACCHARIDE RECOGNITION BY SELECTINS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF MULTIVALENT SIALYL-LEWIS-X LIGANDS

Authors
KRETZSCHMAR G SPRENGARD U KUNZ H BARTNIK E SCHMIDT W TOEPFER A HORSCH B KRAUSE M SEIFFGE D
Citation
G. Kretzschmar et al., OLIGOSACCHARIDE RECOGNITION BY SELECTINS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF MULTIVALENT SIALYL-LEWIS-X LIGANDS, Tetrahedron, 51(47), 1995, pp. 13015-13030
Citations number
45
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
47
Year of publication
1995
Pages
13015 - 13030
Database
ISI
SICI code
0040-4020(1995)51:47<13015:ORBS-S>2.0.ZU;2-8
Abstract
Trivalent sialyl Lewis-X ligands 6-8 anchored onto flexible templates have been synthesized and evaluated as inhibitors of E-selectin and P- selectin mediated cell adhesion in cell culture assays and in vivo. Bi ological activities in vitro correlated with spacer length and lead to ligands with 3-fold (E-selectin) and 5-fold (P-selectin) improved rec eptor binding avidity per single tetrasaccharide moiety.