ALLOGENEIC PERIPHERAL-BLOOD PROGENITOR-CELL TRANSPLANT AFTER BONE-MARROW GRAFT FAILURE - REPORT OF A CASE

A 31 year-old woman diagnosed with acute myelocytic leukemia received an allogeneic peripheral blood progenitor cell (PBPC) transplant one m onth after a previous bone marrow graft failed. PBPCs were mobilized w ith granulocyte-colony-stimulating factor and collected by apheresis. T-cell depletion was not performed and no further chemo- or radiothera py was given for the second transplant. Engraftment was prompt, with t he peripheral blood leukocyte count rising dramatically to 2,400/mu L, six days after completion of PBPC transplant. The platelet count reac hed 36,000/mu L on the eighth day and nas self-sustained thereafter. B oth blood grouping and bone marrow karyotyping confirmed donor origin of the engraftment. At the time of writing, the patient has been disea se-free for over 200 days without any complications of acute or chroni c graft-versus-host disease.