CENTRAL 5-HT4 RECEPTORS

Activation of the 5-HT4 receptor mediates widespread effects in centra l and peripheral nervous systems. Recent developments, such as the ide ntification of novel, selective agonists and antagonists, as well the cloning of the receptor, have provided insights into the physiological role of the receptor. In this article, Richard Eglen and colleagues a ssess the emerging evidence relating to the function of the 5-HT4 rece ptor in the brain. The cerebral distribution of the receptor, along wi th neurochemical and electrophysiological data, suggests a role in cog nition. The role of the receptor in modulation of dopamine transmissio n and anxiolysis is also addressed.