ENYNE METATHESIS USING CHROMIUM CARBENE COMPLEXES - SYNTHESIS OF HETEROCYCLES FROM ENYNES USING CHROMIUM CARBENE COMPLEXES

A new synthesis of pyrrolidine and piperidine derivatives via a chroma cyclobutane formed from a Fischer carbene complex and an enyne having nitrogen in a tether was developed. As the results of the substituent effects, the reaction of enynes having the electron-donating group on the alkene with a Fischer chromium carbene complex in CH3CN afforded p referentially metathesis products, and that of the enyne having the el ectron-withdrawing group gave the cyclized product fused with a cyclop ropane ring.