CLONING AND CHARACTERIZATION OF THE STREPTOMYCES-PEUCETIUS DNRQS GENES ENCODING A DAUNOSAMINE BIOSYNTHESIS ENZYME AND A GLYCOSYL TRANSFERASE INVOLVED IN DAUNORUBICIN BIOSYNTHESIS

Authors
OTTEN SL LIU XC FERGUSON J HUTCHINSON CR
Citation
Sl. Otten et al., CLONING AND CHARACTERIZATION OF THE STREPTOMYCES-PEUCETIUS DNRQS GENES ENCODING A DAUNOSAMINE BIOSYNTHESIS ENZYME AND A GLYCOSYL TRANSFERASE INVOLVED IN DAUNORUBICIN BIOSYNTHESIS, Journal of bacteriology, 177(22), 1995, pp. 6688-6692
Citations number
47
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
177
Issue
22
Year of publication
1995
Pages
6688 - 6692
Database
ISI
SICI code
0021-9193(1995)177:22<6688:CACOTS>2.0.ZU;2-M
Abstract
The dnrQS genes from the daunorubicin producer Streptomyces peucetius were characterized by DNA sequencing, complementation analysis, and ge ne disruption. The dnrQ gene is required for daunosamine biosynthesis, and dnrS appears to encode a glycosyltransferase for the addition of the 2,3,6-trideoxy-3-aminohexose, daunosamine, to epsilon-rhodomycinon e.