Ym. Hui et al., EFFECT OF PERINDOPRIL AND METOPROLOL ON LEFT-VENTRICULAR HYPERTROPHY AND PERFORMANCE IN ESSENTIAL-HYPERTENSION, Chinese medical journal, 108(9), 1995, pp. 678-681
The effects of perindopril and metoprolol on left ventricular hypertro
phy (LVH) and function were studied in 47 essential hypertensive patie
nts with LVH. Previous antihypertensive drugs were discontinued for at
least 2 weeks, after which patients were randomly divided into 2 grou
ps. 25 subjects were treated with perindopril 4 to 8 mg once daily in
the morning (Group A) and 22 subjects with metoprolol 25 to 62.5 mg tw
ice daily (Group B). The subjects were evaluated before and after 4 an
d 8 weeks of treatment by use of echocardiography. Before treatment LV
mass indexes (LVMI) of two groups were respectively 143.2 +/- 21.3 g/
m(2) and 140.6 +/- 23.7 g/m(2) (P>0.05). In Group A, reduction of LVMI
occurred after 4 weeks of treatment, and more pronounced after 8 week
s (from 143.2 +/- 21.3 g/m(2) to 126.6 +/- 15.3 g/m(2), P<0.001), wher
eas reduction of LVMI occurred only after 8 weeks in Group B (from 140
.6 +/- 23.7 g/m(2) to 133.4 +/- 13.2 P<0.001). In addition, there was
a significant (P<0.05) difference in LVMI between the two groups after
8 weeks. LV systolic function remained unchanged, whereas E/A increas
ed significantly (P<0.001) in two groups after 8 weeks In conclusion,
antihypertensive treatment with perindopril and metoprolol induced a s
ignificant regression of LVH associated with improvement in LV diastol
ic performance. Perindopril, compared with metoprolol, was more effect
ive in reversing LVH.