H. Niina et al., INHIBITION OF CATECHOLAMINE SYNTHESIS BY PROADRENOMEDULLIN N-TERMINAL-20-PEPTIDE IN CULTURED BOVINE ADRENAL-MEDULLARY CELLS, European journal of pharmacology, 286(1), 1995, pp. 95-97
In cultured bovine adrenal medullary cells, proadrenomedullin N-termin
al 20 peptide (PAMP), at concentrations greater than or equal to 3 mu
M, inhibited carbachol-induced [C-14]catecholamine synthesis from [C-1
4]tyrosine. Carbachol-induced activation of tyrosine hydroxylase was a
lso attenuated by PAMP. These results suggest that PAMP is a novel end
ogenous peptide that regulates catecholamine synthesis via the suppres
sion of its rate-limiting enzyme in adrenal medullary cells.