SUCCESSFUL TREATMENT OF GENERALIZED LICHEN-PLANUS WITH RECOMBINANT INTERFERON ALFA-2B

Authors
HILDEBRAND A KOLDE G LUGER TA SCHWARZ T
Citation
A. Hildebrand et al., SUCCESSFUL TREATMENT OF GENERALIZED LICHEN-PLANUS WITH RECOMBINANT INTERFERON ALFA-2B, Journal of the American Academy of Dermatology, 33(5), 1995, pp. 880-883
Citations number
13
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Journal of the American Academy of Dermatology → ACNP
ISSN journal
01909622
Volume
33
Issue
5
Year of publication
1995
Part
2
Pages
880 - 883
Database
ISI
SICI code
0190-9622(1995)33:5<880:STOGLW>2.0.ZU;2-E
Abstract
Three patients with generalized lichen planus were treated with interf eron alfa-2b. The therapy was tolerated well by all patients with only minor side effects. A response was observed within 2 to 3 weeks. Itch ing and erythema decreased first, followed by gradual flattening and d isappearance of papules and plaques after 8 to 10 weeks of treatment. After 12 weeks, therapy was discontinued after stepwise dosage reducti on. In two patients, minor lesions recurred during dosage reduction. B oth flares were controlled by readministration of interferon.