H. Hashimoto et al., CENTRAL HYPOTHYROIDISM RESULTING FROM PITUITARY SUPPRESSION AND PERIPHERAL THYROTOXICOSIS IN A PREMATURE-INFANT BORN TO A MOTHER WITH GRAVES-DISEASE, The Journal of pediatrics, 127(5), 1995, pp. 809-811
We observed the sequential changes in serum thyroid hormones and thyro
id-stimulating hormone receptor antibodies in an infant born at 30 wee
ks of gestation to a mother with florid Graves disease. Transient cent
ral hypothyroidism caused by pituitary suppression was observed after
the resolution of peripheral thyrotoxicosis induced by thyroid-stimula
ting antibody. Central hypothyroidism became overt when the suppressio
n of the pituitary gland after fetal thyrotoxicosis was combined with
weak activity of thyroid-stimulating antibody after birth.