BONE-MINERAL DENSITY DURING TREATMENT OF CENTRAL PRECOCIOUS PUBERTY

Treatment of adults with gonadotropin releasing hormone analogs has re sulted in rapid loss in bone mineral density (BMD). We measured lumbar and femoral neck BMD by dual-energy x-ray absorptiometry during 2 yea rs of depot leuprolide therapy in 13 girls (mean age, 7.5 years; mean bone age, 10.9 years). At baseline, BMD was elevated for age and conco rdant with the advanced skeletal age, During therapy with gonadotropin releasing hormone analog, BMD values increased and BMD standard devia tion scores for age and skeletal age did not change.