APOLIPOPROTEIN-E IN SPORADIC AND FAMILIAL CREUTZFELDT-JAKOB-DISEASE

We assessed the apolipoprotein E (ApoE) genotype in 49 sporadic and te n familial Creutzfeldt-Jakob disease (CJD) patients, in seven healthy siblings with a PRNP mutation and in 84 controls. In sporadic CJD, Apo E genotypes and allelic frequencies do not significantly differ from t hat of controls. No influence of ApoE genotypes on age at onset was fo und. In familial cases, the disease appeared in mutated subjects showi ng the same ApoE genotype as members who have not yet developed CJD. O ur results provide further evidence that ApoE is not a risk factor for CJD.