AIT-082, A UNIQUE PURINE DERIVATIVE, ENHANCES NERVE GROWTH-FACTOR MEDIATED NEURITE OUTGROWTH FROM PC12 CELLS

Authors
MIDDLEMISS PJ GLASKY AJ RATHBONE MP WERSTUIK E HINDLEY S GYSBERS J
Citation
Pj. Middlemiss et al., AIT-082, A UNIQUE PURINE DERIVATIVE, ENHANCES NERVE GROWTH-FACTOR MEDIATED NEURITE OUTGROWTH FROM PC12 CELLS, Neuroscience letters, 199(2), 1995, pp. 131-134
Citations number
16
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
199
Issue
2
Year of publication
1995
Pages
131 - 134
Database
ISI
SICI code
0304-3940(1995)199:2<131:AAUPDE>2.0.ZU;2-S
Abstract
AIT-082 is a novel, metabolically stable, derivative of the purine hyp oxanthine. Addition of AIT-082 to cultured PC12 cells enhanced signifi cantly nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. These results suggest a cellular mechanism, the enhancement of NGF-action, that might account for the ability of AIT-082 to restore a ge-induced working memory deficits in mice.