Gj. Temeerman et al., PERSPECTIVES OF IDENTITY BY DESCENT (IBD) MAPPING IN FOUNDER POPULATIONS, Clinical and experimental allergy, 25, 1995, pp. 97-102
In a founder population patients with a genetic disease are likely to
share predisposing genes from a common ancestor. We show that, dependi
ng on the distance of the relationship, patients are expected to share
extended segments of DNA around the disease gene. Because of the size
of the shared segment, a genomic search with DNA markers for such sha
red segments, identity by descent (IBD) mapping, can efficiently find
the map position of genes, particularly due to genetic drift leading t
o reduction of heterogeneity and the large number of meioses that is i
mplicitly observed. The statistical power of this method and the appro
ximate cost are given as a function of the density of the map of teste
d markers and the number of generations since a common ancestor. Initi
al marker spacings between 5 and 15 centiMorgans are shown to be optim
al. IBD mapping is applicable to many genetic diseases, because it doe
s not presuppose a specific genetic model.