Authors
Citation
N. Papadopoulos, INTRODUCTION TO POSITIONAL CLONING, Clinical and experimental allergy, 25, 1995, pp. 116-118
Citations number
16
Categorie Soggetti
Allergy,Immunology
Journal title
ISSN journal
09547894
Volume
25
Year of publication
1995
Supplement
2
Pages
116 - 118
Database
ISI
SICI code
0954-7894(1995)25:<116:ITPC>2.0.ZU;2-7
Abstract
The most common procedure for isolating genes that predispose to a cer
tain disease is positional cloning. This process is initiated by mappi
ng the responsible gene to its location on a chromosome linked to the
disease. Successive cloning of the region results in the isolation of
candidate genes. Finally, identification of mutations by mutational an
alysis points to the correct gene.