URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE DETERMINATION IN NEWBORNS ANDCHILDREN - METHODS AND DIAGNOSTIC APPLICATIONS

More recently numerous papers have been written on the successful paed iatric applications of some well-established urinary N-acetyl-beta-D-g lucosaminidase assays by several authors. Regarding these developments we tried to collect and summarize all the available literature data p ublished in this field thus far and, in addition, to encourage and pro mote the wider utilization of these effective methods for the diagnosi s of very different primary and secondary renal damages. Besides the c hemical and biochemical background of the assays the pathological cond itions and medical treatments which may lead to tubulopathy and, there fore, to a significantly elevated urinary enzyme excretion are also di scussed.