STUDIES OF DEMENTIA, DEPRESSION, ELECTROPHYSIOLOGY AND CEREBROSPINAL-FLUID MONOAMINE METABOLITES IN PATIENTS WITH PARKINSONS-DISEASE

Twenty-two patients with Parkinson's disease (PD) were studied by clin ical evaluation, assessments of dementia and depression, as well as el ectrophysiologic examinations for blink reflex (BR), cortical somatose nsory evoked potentials (CSEP), brain stem, and long-latency auditory evoked potentials (BAEP, and LAEP), and cerebrospinal fluid (CSF) assa ys for monoamine metabolites. Results show that PD patients have a sig nificant decrease of Mini-Mental State Examination (MMSE) scores (p < 0.05) and an increase of Hamilton Depression Scale (HDS) scores (p < 0 .01), as well as a longer latencies of R2 in BR, N19 and P22 in CSEP, W4 and W5 in BAEP and P300 in LAEP (p < 0.01), and lower CSF levels of HVA and MHPG (p < 0.05). The findings suggest a correlation between d ementia/depression and mesocorticolimbic and mesostriatocortic dysfunc tion with dopaminergic and noradrenergic deficiencies in PD patients. Furthermore, parkinsonian dementia parallels the length of duration of the disease, but not the severity of motor disability. Parkinsonian d epression parallels both the length of duration of the disease and the severity of motor disability.