M. Poss et al., DIVERSITY IN VIRUS POPULATIONS FROM GENITAL SECRETIONS AND PERIPHERAL-BLOOD FROM WOMEN RECENTLY INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, Journal of virology, 69(12), 1995, pp. 8118-8122
In order to develop a human immunodeficiency virus type I vaccine with
global efficacy, it is important to evaluate the virus populations th
at are transmitted to individuals living in high-incidence areas. To d
etermine the nature of the human immunodeficiency virus type 1 populat
ion transmitted to women during heterosexual contact, we examined the
diversity of the proviral envelope gene in infected cells in both geni
tal secretions and peripheral blood from six recently seroconverted Ke
nyan women. Heterogeneous virus populations were present in cervical s
ecretions and/or peripheral blood shortly after seroconversion for fiv
e of six infected individuals, and tissue-specific variants were ident
ified in several cases.