EPSTEIN-BARR-VIRUS INDUCTION OF RECOMBINASE-ACTIVATING GENES RAG1 ANDRAG2

Authors
SRINIVAS SK SIXBEY JW
Citation
Sk. Srinivas et Jw. Sixbey, EPSTEIN-BARR-VIRUS INDUCTION OF RECOMBINASE-ACTIVATING GENES RAG1 ANDRAG2, Journal of virology, 69(12), 1995, pp. 8155-8158
Citations number
46
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
69
Issue
12
Year of publication
1995
Pages
8155 - 8158
Database
ISI
SICI code
0022-538X(1995)69:12<8155:EIORGR>2.0.ZU;2-N
Abstract
In experimental B-cell infections, Epstein-Barr virus induced sustaine d expression of V(D)J recombinase-activating genes RAG1 and RAG2, whos e aberrant activity has been implicated in chromosomal translocations in B-cell neoplasms. In cell lines in which RAG1 and RAG2 were detecte d, virus integrated into cellular DNA rather than assumed the configur ation of extrachromosomal episomes. Expression of the Epstein-Barr vir us nuclear antigen 1 in transient transfection assays was sufficient t o induce both recombinase-activating genes.