A SUBLOCUS OF THE MULTICOPY MICROSATELLITE MARKER CMS1 MAPS PROXIMAL TO SPINAL MUSCULAR-ATROPHY (SMA) AS SHOWN BY RECOMBINANT ANALYSIS

Authors
VANDERSTEEGE G COBBEN JM OSINGA J SCHEFFER H VANOMMEN GJB BUYS CHCM
Citation
G. Vandersteege et al., A SUBLOCUS OF THE MULTICOPY MICROSATELLITE MARKER CMS1 MAPS PROXIMAL TO SPINAL MUSCULAR-ATROPHY (SMA) AS SHOWN BY RECOMBINANT ANALYSIS, Human genetics, 96(5), 1995, pp. 589-591
Citations number
18
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
96
Issue
5
Year of publication
1995
Pages
589 - 591
Database
ISI
SICI code
0340-6717(1995)96:5<589:ASOTMM>2.0.ZU;2-3
Abstract
The critical region containing the spinal muscular atrophy (SMA) gene is flanked by the 5q11-q13 markers, D5S435 and D5S557, as determined b y linkage analysis. Here we present the results of an analysis of a Du tch SMA family with the multicopy microsatellite marker CMS1. A crosso ver is revealed in the critical SMA region. We conclude that at least one of the CMS1 subloci maps proximal to the SMA gene. This reduces th e minimal SMA region from approximately 1.4 Mb to 600-700 kb.