ASSOCIATION OF APOLIPOPROTEIN-E BUT NOT APOLIPOPROTEIN-B WITH ALZHEIMERS-DISEASE

In our studies apolipoprotein E4 (APOE4) is associated with both early - and late-onset Alzheimer's disease. Alzheimer's patients from West T exas were screened for the APOE4 allele, which was found at frequencie s of 0.43 and 0.59 in familial late- and early-onset cases. Sporadic c ases had lower frequencies, but they still were 2-4 times higher than control spouses. To determine whether the APOE association may be a ri sk factor for coronary disease as well, we examined two APOB gene rest riction sites that have previously been found to be associated with co ronary artery disease, especially myocardial infarctions. The APOB all eles were found at similar frequencies in Alzheimer's patients and con trol spouses.