A 2.1-kb cDNA probe encoding the human SH2-domain containing protein-t
yrosine phosphatase SH-PTP2 (PTPN11) was hybridized to human metaphase
chromosomes in three independent experiments. In each instance, hybri
dization was maximal to chromosome 12q24.1-q24.3. The presence of SH-P
TP2 cDNA crosshybridizing sequences located on a number of other chrom
osomes suggested that SH-PTP2-related genes or pseudogenes are present
in the human genome.