Stress is a term that is readily recognized by everyone but defines ri
gorous scientific definition. It is widely interpreted as the emotiona
l and biologic responses to novel or threatening situations. In humans
, however, the term ''distress'' seems to be preferable, more clearly
defining the fact that is the response that is being referred to, rath
er than the stimulus. Distress has been postulated to be capable of pr
ecipitating an overt illness, as when it occurs coincidentally with an
incipient infection or neoplasm. Moreover, it is able to provoke seve
ral disorders and symptoms in many tissues and organs, including the s
kin. In this paper the authors focus on the main characteristics of st
ress and emphasize the relevance of psychosomatic medicine that propos
es the simultaneous examination of psyche and soma. Special considerat
ion is given to a peculiar form of skin disease, psychogenic purpura,
together with the stigmata of mystics that, in large part, seem to be
conditioned or provoked (or provocable) by emotional stress or by psyc
hic influences on cutaneous fibrinolytic activity.