THE TRANSFORMATIONS OF 4-HETEROARYLAMINOMETHYLENE-5(4H)-OXAZOLONES INTO DEHYDROPEPTIDE DERIVATIVES

Authors
ALJAZROZIC M SVETE J STANOVNIK B
Citation
M. Aljazrozic et al., THE TRANSFORMATIONS OF 4-HETEROARYLAMINOMETHYLENE-5(4H)-OXAZOLONES INTO DEHYDROPEPTIDE DERIVATIVES, Journal of heterocyclic chemistry, 32(5), 1995, pp. 1605-1611
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
32
Issue
5
Year of publication
1995
Pages
1605 - 1611
Database
ISI
SICI code
0022-152X(1995)32:5<1605:TTO4I>2.0.ZU;2-U
Abstract
Phenyl-4-heteroarylaminomethylene-5(4H)-oxazolones 3, which were prepa red from the corresponding N,N-dimethyl-N'-heteroarylformamidines 1 an d hippuric acid 2 in acetic anhydride, react with amino acids giving d ehydropeptide derivatives 4, 5, and 6 as products. Dehydration of N-pr otected peptides 7-10, containing glycine at the C-terminal, followed by the reaction with formamidines 1 gave ituted-4-heteroarylaminomethy lene-5(4H)-oxazolones 11-14.