SYNTHESIS OF ALPHA-2'-DEOXYNUCLEOSIDES

Authors
LARSEN E ALEEM AAHA PEDERSEN EB
Citation
E. Larsen et al., SYNTHESIS OF ALPHA-2'-DEOXYNUCLEOSIDES, Journal of heterocyclic chemistry, 32(5), 1995, pp. 1645-1646
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
32
Issue
5
Year of publication
1995
Pages
1645 - 1646
Database
ISI
SICI code
0022-152X(1995)32:5<1645:SOA>2.0.ZU;2-N
Abstract
alpha-Thymidine (4) was synthesized from thymidine (1) in 3 steps in 3 6% overall yield without using chromatography and with the possibility of increasing the yield to 85% by reusing the remaining alpha,beta-mi xture. O-p-toluoyl-alpha-D-erythro-pentofuranosyl)thymine (3) was furt her converted to y-alpha-D-erythro-pentofuranosyl)-5-methylcytosine (5 ).