AN APPROACH TO SUBSTITUTED 4-HYDROXYPYRAN-2-ONES

Authors
RAMIREZ M GAREY D PENA MR
Citation
M. Ramirez et al., AN APPROACH TO SUBSTITUTED 4-HYDROXYPYRAN-2-ONES, Journal of heterocyclic chemistry, 32(5), 1995, pp. 1657-1660
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
32
Issue
5
Year of publication
1995
Pages
1657 - 1660
Database
ISI
SICI code
0022-152X(1995)32:5<1657:AATS4>2.0.ZU;2-O
Abstract
We examined a method for the preparation of 4-hydroxypyran-2-ones in t wo steps from aryl ketones and ethyl malonyl chloride (or ethyl 2-meth ylmalonyl chloride). These 4-hydroxypylan-2-ones are useful precursors as they may be transformed in two steps to the 2-methoxypyran-4-ones, which is found in phenoxan - a naturally occurring compound discovere d to have anti-HIV activity.