M. Derosa et Aj. Freyer, NOE DIFFERENCE SPECTROSCOPY OF SOME 5-SUBSTITUTED AND 5,5-DISUBSTITUTED HYDANTOINS, Journal of heterocyclic chemistry, 32(5), 1995, pp. 1661-1663
The nOe difference (NOED) spectra of twelve 5-substituted- and 5,5-dis
ubstituted hydantoins were recorded in deuteriochloroform. The nOe's o
bserved from the interaction of substituents on C-5 with the proton on
N-1 are more reliable than the chemical shift of the N-1 proton for s
tructure determination.