DE-NOVO MALIGNANCY FOLLOWING RENAL-TRANSPLANTATION - AS SEEN IN SAUDI-ARABIA

Objectives: To study incidence and type of postrenal transplant de nov o malignancy. Setting: A total of 730 postrenal transplant patients fo llowed up in our unit for a mean period of 5.3 years was studied retro spectively for development of malignancy. Results: In 48 patients (6.5 %) 49 malignancies developed. Of the 48 patients, 36 developed Kaposi' s sarcoma and nine patients developed solid tumours (kidney (1), liver (2), thyroid (2), nasopharynx (1), urinary bladder (1), uterus (1), m etastasizing adenocarcinoma of unknown aetiology (1)). Three patients developed non-Hodgkin's lymphoma of diffuse large cell type. The avera ge time from transplantation to development of solid tumours was 7.1 y ears and for skin tumours was 15.9 months. The paper analyses these fi ndings and compares them with that of the Saudi general population as well as a posttransplant Western population.