Objective. To assess the extent to which hospitals in a midwestern sta
te with low acute hepatitis B virus (HBV) morbidity offered hepatitis
B (Hep B) vaccine to all infants, whether offering infants Hep B vacci
ne was associated with hospital geographic location or size, as measur
ed by the number of births, and how hospital staff resolved key progra
mmatic issues. Methods. The managers of hospital newborn nurseries (N
= 110) were surveyed by mail. The written response rate was 72%; all o
f the nonresponders were interviewed by telephone. The outcome measure
d was the number of hospitals offering Hep B vaccine to all infants by
geographic region and hospital size. Results. Sixty-five percent of t
he hospitals routinely offered Hep B vaccine to all infants; these hos
pitals accounted far 80% of reported Wisconsin births. In univariate a
nalysis, the decision to offer infants Hep B vaccine was associated wi
th both hospital size and hospital location. After controlling for siz
e, hospitals in the northeastern region were eight times more likely (
relative risk, 8.21; 95% confidence interval, 1.30, 51.79) to offer in
fants Hep B vaccine than hospitals in the southeastern (referent) regi
on. Regional differences in reported rates of acute HBV infection do n
ot explain this finding, because morbidity in the northeastern region
(1 per 100 000) is among the lowest in Wisconsin. Although more than 8
0% of hospitals with Hep B vaccination programs required written infor
med consent for vaccination, had standing orders for administering Hep
B vaccine to infants whose mothers' hepatitis B surface antigen (HBsA
g) test results were known, and had mechanisms to notify the infants'
physicians that the infants had been vaccinated, only 38% had standing
orders for testing mothers whose HBsAg test results were unknown. Con
clusions. Hospitals are not necessarily deterred from implementing inf
ant Hep B vaccination programs by low community HBV morbidity. Hospita
ls should develop policies to assure that parturient women with unknow
n HBsAg status are screened and their infants are appropriately treate
d.