Sickle trait is traditionally considered a benign condition by ophthal
mologists. Three cases of sickle retinopathy in subjects with sickle t
rait are reported. In all cases the onset of retinopathy was related t
o other contributing factors: in one case a traumatic hyphaema and rai
sed intraocular pressure, in two others diabetes mellitus. Patients,vi
th sickle trait are at risk of retinopathy if coincident ocular or sys
temic disease is present.