LIQUID-CHROMATOGRAPHIC DETERMINATION OF DICLOXACILLIN PREPARATIONS - INTERLABORATORY STUDY

A previously published liquid chromatographic method proposed for the analysis of dicloxacillin preparations was subjected to an interlabora tory study. The method is rigorously defined in terms of performance r equirements, yet allows a degree of flexibility to the individual anal yst. Eight laboratories participated in a study to analyze 3 samples i n duplicate. Estimates for the repeatability and reproducibility of th e method, expressed as relative standard deviations of the results of the determination of dicloxacillin preparations, were <0.57 and 2.56%, respectively.