ALIEN HAND SIGN IN ASSOCIATION WITH ALZHEIMERS HISTOPATHOLOGY

A 68 year old man is described with an alien left hand, cortical myocl onus, bilateral parietal lobe dysfunction and memory impairment but pr eserved language skills. The clinical diagnosis was of corticobasal de generation but at necropsy, four years after the onset of symptoms, th e pathology was of Alzheimer's disease together with some scattered ch romatolytic pale neurons in the cerebral cortex. The alien hand sign h as not previously been described in Alzheimer's dementia and is an ill ustration of the clinical heterogeneity that may occur in association with Alzheimer histopathology.