NEUROMAGNETIC signals evoked by synthesized syllables (/b dipthong ae/
and /g dipthong ae/) were recorded over the left auditory cortex of h
ealthy humans. The fundamental frequencies of the syllables varied as
if the same speaker had pronounced them at 16 different pitches. Speci
fic mismatch responses to infrequent syllables among frequent syllable
s of the other type indicated that phonetically invariant information
had been extracted at the level of the auditory cortex from the extens
ive irrelevant pitch variation. Such a detection mechanism is necessar
y for perceiving speech sounds in natural situations with a great deal
of acoustic variation present.