METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS (MRSA) COLONIZATION IN PATIENTS WITH SPINAL-CORD INJURY

Methicillin-resistant Staphylococcus aureus (MRSA) colonization has be en a problem in the Rancho Los Amigos Medical Center (RLAMC) since 197 8. This study reviews the latest 2 years' use of a protocol to prevent the spread of MRSA while allowing spinal cord injured patients to con tinue to participate in the rehabilitation program. The protocol inclu ded management in a private room, bathing with hexachlorophene, monito ring positive sites and clearing patients after 3 weeks of negative cu ltures. Clusters of cases were investigated by obtaining nasal culture s from the personnel. Sixty-seven of 584 (11%) SCI patients were colon ized from July 1989 to July 1991. The prevalence of MRSA colonization was significantly greater in the pressure ulcer management service (PM S) 49/184 (27%) than in the rehabilitation spinal injury service (SIS) 18/400 (5%). The body sites colonized were wounds (58/67), nares (37/ 67), throat (30/67), urine (27/67) and perineum (17/67). Oral therapy with combinations of sulfamethoxazole trimethoprim (SXT) or Novobiocin with rifampin together with topical antibiotics (nares and wound site s), used in nine patients with healing wounds or recent flap surgery, resulted in clearing of the colonization in all cases. Identification and treatment of carriers in the personnel and use of preadmission scr eening cultures for MRSA in patients with pressure ulcers resulted in reduced inpatient admission.